MS 2000 num. 04
http://hdl.handle.net/10608/274
2024-03-28T15:59:43ZBrèves
http://hdl.handle.net/10608/1700
Brèves
2000-01-01T00:00:00ZLes gènes modificateurs dans les maladies héréditaires.
http://hdl.handle.net/10608/1699
Les gènes modificateurs dans les maladies héréditaires.
Feingold, J
Many hereditary diseases are phenotypically variable. The phenotype can be more or less severe between families and within families. Three main factors can cause this phenotypic variability: allelic and non allelic heterogeneity, modifying genes, environmental differences. Modifiying genes which, while not causing the disease may be related to its severity. The modifiying genes can concern a qualitative feature of the disease, i.e. different subsets of organs can be affected, or a quantitative one, a different age of onset can be noted. Three groups of modifier genes can be considered: (1) Allelic or heteroallelic variants of the deleterious gene. (2) Genes very closely linked to the deleterious allele (chromosomal background). (3) non allelic genes. Strategies for the identification of modifiying genes are similar to those used in genetic epidemiology. Two methods are used, association studies and affected sibling pairs analysis. In both cases the candidate gene approache is privileged. Understanding the pathogenesis of a disease and/or animal models may provide clues to likely candidate genes. [References: 28]
2000-01-01T00:00:00ZUn nouveau gène de fusion dans les leucémies aiguës promyélocytaires.
http://hdl.handle.net/10608/1697
Un nouveau gène de fusion dans les leucémies aiguës promyélocytaires.
Philippe, C; Arnould, C; Bourdon, V; Grégoire, MJ; Berger, R; Jonveaux, P
2000-01-01T00:00:00ZPREVENT, le premier essai de thérapie génique randomisé dans le traitement des maladies artérielles.
http://hdl.handle.net/10608/1698
PREVENT, le premier essai de thérapie génique randomisé dans le traitement des maladies artérielles.
Allaire, E; Desgranges, P; Cron, J; d'Audiffret, A; Mellière, D; Becquemin, JP
2000-01-01T00:00:00Z