Modèle d'étude de l'insertion des protéines membranaires
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Colicin A from Citrobacter freundii and aerolysin from Aeromonas hydrophila are representative of two classes of pore-forming toxins. Colicin A, an alpha-helical protein, contains an hydrophobic hairpin which is buried inside the structure in solution. It is an << inside out >> membrane protein. Aerolysin is formed almost exclusively of beta-sheet and possesses a very hydrophilic amino acid sequence. It is secreted as an inactive precursor which is activated by proteolytic removal of about 41-43 residues from the C-terminus. The mechanism of membrane insertion and the structure of the membrane bound form of these toxins are discussed.
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Vandergoot, F.G. ; Pattus, F., Modèle d'étude de l'insertion des protéines membranaires, Med Sci (Paris), 1993, Vol. 9, N° 2; p.171-178