dc.contributor.author | Wang, Huafu | - |
dc.contributor.author | Gang, Huang | - |
dc.contributor.author | Zhou, Shuxin | - |
dc.contributor.author | Liu, Lixian | - |
dc.contributor.author | Ding, Ting | - |
dc.contributor.author | Gui, Zhihong | - |
dc.contributor.author | Chu, Weihua | - |
dc.date.accessioned | 2019-11-05T12:51:14Z | |
dc.date.available | 2019-11-05T12:51:14Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Wang, Huafu ; Gang, Huang ; Zhou, Shuxin ; Liu, Lixian ; Ding, Ting ; Gui, Zhihong ; Chu, Weihua ; Liuwei Dihuang exhibits antidiabetic effects through inhibiting α-amylase and α-glucosidase, Med Sci (Paris), , Vol. 34, N° HS ; p. 4-7 ; DOI : 10.1051/medsci/201834f101 | |
dc.identifier.issn | 1958-5381 | |
dc.identifier.uri | http://hdl.handle.net/10608/9978 | |
dc.description.abstract | Objective: Liuwei Dihuang (LWDH) is a famous traditional herbal medicine formula in China that may regulate the balance of kidney yin yang and has been used to restore functional insufficiency of the kidney for a long time in China. Methods: In this study, the water extract of LWDH was tested for its α-Amylase and α-Glucosidase inhibitory activities, and its anti-diabetic property in streptozotocin (STZ)-induced diabetic mice was also analyzed. Results: LWDH extract inhibited α-Glucosidase and α-Amylase activities in a dose- dependent manner. Treatment of streptozotocin-induced diabetic mice with LWDH extract decreased camp, fasting blood glucose, TC, TG, LDL-c, HbA1C, Urine volume levels and Urine sugar, increased HDL-c level when compared to STZ induced diabetic mice. Conclusion: This study demonstrates that extract of LWDH can inhibit α-amylase and α-glucosidase activities and shows anti-diabetic effect in a mice preclinical model. | en |
dc.language.iso | en | |
dc.publisher | EDP Sciences | |
dc.rights | Article en libre accès | fr |
dc.rights | Médecine/Sciences - Inserm - SRMS | fr |
dc.source | M/S. Médecine sciences [ISSN papier : 0767-0974 ; ISSN numérique : 1958-5381], , Vol. 34, N° HS; p. 4-7 | |
dc.title | Liuwei Dihuang exhibits antidiabetic effects through inhibiting α-amylase and α-glucosidase | en |
dc.type | Article | |
dc.contributor.affiliation | Department of pharmacy, Lishui People’s Hospital, the Sixth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China | |
dc.contributor.affiliation | Department of Traditional Chinese Medicine, Lishui People’s Hospital, the Sixth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China | |
dc.contributor.affiliation | School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, P.R. China | |
dc.contributor.affiliation | Department of Nephrology, Lishui People’s Hospital, the Sixth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China | |
dc.identifier.doi | 10.1051/medsci/201834f101 | |