dc.contributor.author | Liu, Sen | - |
dc.contributor.author | Liu, Hongyu | - |
dc.contributor.author | Dong, Yunlong | - |
dc.contributor.author | Wang, Fengbiao | - |
dc.contributor.author | Wang, Huijuan | - |
dc.contributor.author | Chen, Jun | - |
dc.date.accessioned | 2019-11-05T12:51:22Z | |
dc.date.available | 2019-11-05T12:51:22Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Liu, Sen ; Liu, Hongyu ; Dong, Yunlong ; Wang, Fengbiao ; Wang, Huijuan ; Chen, Jun ; Gastric carcinoma with a gastrointestinal stromal tumor : A case report and literature review, Med Sci (Paris), , Vol. 34, N° HS ; p. 15-19 ; DOI : 10.1051/medsci/201834f103 | |
dc.identifier.issn | 1958-5381 | |
dc.identifier.uri | http://hdl.handle.net/10608/9980 | |
dc.description.abstract | Gastric carcinoma (GC) with gastrointestinal stromal tumor (GIST) is encountered very rarely in the clinic, and few cases have been reported in the literature. Here, we present a case involving a 72-year-old man who was diagnosed with gastric antrum adenocarcinoma accompanied by neuroendocrine differentiation and a GIST in the fundus, according to a preoperative examination and postoperative pathology. The patient then underwent a distal radical gastrectomy and GIST resection. After the operation, the patient was administered combined chemo-radiotherapy and subsequently underwent a 9-month follow-up examination. The gene mutations involved in this case were explored via high-throughput sequencing. The high-throughput gene mutation analysis indicated an exon5 mutation in the TP53 gene and copy number amplification of FGF19, CCND1, and FGFR2 in the gastric antrum adenocarcinoma. A gene sequencing analysis of the gastric fundus stromal tumor demonstrated an exon11 non-frame shift deletion mutation in the KIT gene. These findings suggested that this patient’s cancer might be sensitive to AZD1775 (a TP53-targeted drug) or targeted drugs such as FGF19, CCND1 and FGFR2, and should be sensitive to imatinib. | en |
dc.language.iso | en | |
dc.publisher | EDP Sciences | |
dc.rights | Article en libre accès | fr |
dc.rights | Médecine/Sciences - Inserm - SRMS | fr |
dc.source | M/S. Médecine sciences [ISSN papier : 0767-0974 ; ISSN numérique : 1958-5381], , Vol. 34, N° HS; p. 15-19 | |
dc.title | Gastric carcinoma with a gastrointestinal stromal tumor : A case report and literature review | en |
dc.type | Article | |
dc.contributor.affiliation | Department of Gastrointestinal Surgery, Tianjin 4th Central Hospital, Hebei District, Tianjin 300140, China | |
dc.contributor.affiliation | Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute | |
dc.contributor.affiliation | Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Heping District, Tianjin 300052, China | |
dc.identifier.doi | 10.1051/medsci/201834f103 | |