dc.contributor.author | Jiang, Qun-Qun | - |
dc.contributor.author | Liu, Wei-Bing | - |
dc.date.accessioned | 2019-11-05T12:51:40Z | |
dc.date.available | 2019-11-05T12:51:40Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Jiang, Qun-Qun ; Liu, Wei-Bing ; miR-25 Promotes Melanoma Progression by regulating RNA binding motif protein 47, Med Sci (Paris), , Vol. 34, N° HS ; p. 59-65 ; DOI : 10.1051/medsci/201834f111 | |
dc.identifier.issn | 1958-5381 | |
dc.identifier.uri | http://hdl.handle.net/10608/9988 | |
dc.description.abstract | Melanoma is the most aggressive skin cancer, and accounts for the major part of skin cancer-related deaths in the world. In addition, the underlying mechanism of tumor progression in melanoma remains far from being elucidated. In this study, we have evaluated the function of miR-25 in melanoma. First, we examined the expression of miR-25 in four melanoma cell lines (A875, MV3, M14 and uacc-257) and in a normal melanocyte cell line (HEM-a). Then, we overexpressed miR-25 in M14 cells. Our results show that miR-25 promotes M14 cell proliferation and migration. We found that miR-25 up-regulates the PI3K/Akt/mTOR signaling pathway in these tumor cells. Furthermore, a luciferase-based reporter gene assay showed that miR-25 could directly target the RNA-binding motif protein 47 (RBM47). Taken together, our findings suggest that RBM47 is a promising target for the treatment of melanoma. | en |
dc.language.iso | en | |
dc.publisher | EDP Sciences | |
dc.rights | Article en libre accès | fr |
dc.rights | Médecine/Sciences - Inserm - SRMS | fr |
dc.source | M/S. Médecine sciences [ISSN papier : 0767-0974 ; ISSN numérique : 1958-5381], , Vol. 34, N° HS; p. 59-65 | |
dc.title | miR-25 Promotes Melanoma Progression by regulating RNA binding motif protein 47 | en |
dc.type | Article | |
dc.contributor.affiliation | Department of Dermatology, 404 Hospital of People’s Liberation Army, No.8 of Baoquan Street, Huancui District, Weihai, 264200, Shandong Province, China | |
dc.identifier.doi | 10.1051/medsci/201834f111 | |