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Voici les éléments 21-30 de 31
Chroniques génomiques - Les sénolytiques contre la Covid-19 ?
(EDP Sciences, 2021)
The elimination of some senescent cells by « senolytic » compounds can greatly improve the health of aged mice and in some cases reverse the effects of aging. Using a microbial exposure system that closely models coronavirus ...
Chroniques génomiques - Mutations somatiques et longévité
(EDP Sciences, 2022)
New approaches allow precise measurement of somatic mutations in tissues. Applied to a diverse set of mammals, these methods show that somatic mutation load increases with age (as expected) but reaches similar levels near ...
Races canines et comportement : Chroniques génomiques
(EDP Sciences, 2022)
It is commonly believed that a dog’s breed predicts its behaviour. A 2019 paper seemed to confirm this, but had some serious limitations. An extensive new study shows that, in fact, breed is not a good predictor of behaviour ...
Vers une thérapie génique pour la progéria ?
(EDP Sciences, 2021)
Hutchinson-Gilford Progeria (acute premature aging) is caused by a de novo point mutation in the lamin A gene. Recently, this mutation has been accurately corrected by base editing in patient cell lines and in a mouse ...
Chroniques génomiques - La « dé-extinction » du mammouth laineux, un « Colossal » canular ?
(EDP Sciences, 2022)
Reports of a mammoth cloning project on-going under George Church’s supervision appear periodically in the press. Close examination of the available evidence indicates that there is indeed such a project (carried out in a ...
Chroniques génomiques - Chiens, loups et gènes
(EDP Sciences, 2022)
The most significant polymorphism associated with dog size occurs in the region of the
IGF1
gene and concerns a single base change in a neighbouring lncRNA. The “small” (C) ...
Chroniques génomiques - Un cadeau empoisonné
(EDP Sciences, 2020)
GWAS analysis of severe Covid patients implicates a major locus on chromosome 3. The corresponding 50 kb segment appears to originate from Neanderthal/Sapiens crossings, raising interesting evolutionary questions.
Chroniques génomiques - Méprise sur les cibles
(EDP Sciences, 2020)
Chroniques génomiques - Néandertal et Afrique, le retour
(Éditions EDK, Groupe EDP Sciences, 2020)
Sophisticated analyses of current human populations compared to a high-coverage Neandertal genome sequence indicate that, contrary to the previous consensus, African genomes carry a small but significant amount of ...
Chroniques génomiques - Tout savoir sur les mutations germinales chez les vertébrés
(EDP Sciences, 2023)
Mutations in the germline are an essential component of evolution. Current DNA sequencing systems allow quantification of these mutations through full genome sequencing of father/mother/child trios. A recent paper reports ...