Parcourir MS 2018 Focus Issue1 par titre
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Analysis of the association between CDH2 gene polymorphism and osteoarthritis risk
(EDP Sciences, 2018)Objective: to define the cadherin 2 (CDH2) gene polymorphism in Chinese osteoarthritis and control populations and to explore the correlation between CDH2 gene polymorphism and the risk of osteoarthritis. Method: a total ... -
Analysis of the long-term efficacy of core decompression with synthetic calcium-sulfate bone grafting on non-traumatic osteonecrosis of the femoral head
(EDP Sciences, 2018)Objective: to investigate the safety and long-term efficacy of core decompression with synthetic calcium-sulfate bone grafting on non-traumatic osteonecrosis of the femoral head. Method: a total of 76 patients with ... -
Bone and dental abnormalities as first signs of familial Gardner’s syndrome in a Chinese family: a literature review and a case report
(EDP Sciences, 2018)Gardner’s syndrome (GS) is an autosomal dominant disease characterized by the presence of familial adenomatous polyposis (FAP) as well as extraintestinal manifestations such as osteomas, dental anomalies, epidermoid cysts ... -
Complement protein C5a enhances the β-amyloid-induced neuro-inflammatory response in microglia in Alzheimer’s disease
(EDP Sciences, 2018)Objective: The dysregulation of neuro-inflammation is one of the attributes of the pathogenesis of Alzheimer’s disease (AD). Over-expression of complement proteins co-localizes with neurofibrillary tangles, thereby indicating ... -
Computational QSAR model combined molecular descriptors and fingerprints to predict HDAC1 inhibitors
(EDP Sciences, 2018)The dynamic balance between acetylation and deacetylation of histones plays a crucial role in the epigenetic regulation of gene expression. It is equilibrated by two families of enzymes: histone acetyltransferases and ... -
Diagnostic efficacy of serum procalcitonin, C-reactive protein concentration and clinical pulmonary infection score in Ventilator-Associated Pneumonia
(EDP Sciences, 2018)Objective: The aim of this study was to evaluate the diagnostic efficacy of serum procalcitonin (PCT), c-reactive protein (CRP) concentration and clinical pulmonary infection score(CPIS) in ventilator-associated pneumonia(VAP). ... -
Effects of continuous positive airway pressure on elderly patients with obstructive sleep apnea: a meta-analysis
(EDP Sciences, 2018)Objective: the aim of the study was to evaluate the efficacy of continuous positive airway pressure (CPAP) for the treatment of obstructive sleep apnea in the elderly. Method: a comprehensive search for qualified clinical ... -
Exploring the dynamic changes between pulmonary and cutaneous sarcoidosis based on gene expression
(EDP Sciences, 2018)Sarcoidosis is a disease involving the growth of abnormal inflammatory granulomas and affecting multisystems. It has an unknown etiology. The lung and the skin are the most commonly involved organs. Although large amounts ... -
Gastric carcinoma with a gastrointestinal stromal tumor : A case report and literature review
(EDP Sciences, 2018)Gastric carcinoma (GC) with gastrointestinal stromal tumor (GIST) is encountered very rarely in the clinic, and few cases have been reported in the literature. Here, we present a case involving a 72-year-old man who was ... -
Incidence and risk factors of the temporomandibular joint disorders in the patients without condylar fractures
(EDP Sciences, 2018)Objective: To evaluate the incidence and risk factors of the temporomandibular joint disorders (TMD) in the patients suffering from maxillo-facial injury without condylar fractures. Methods: sixty patients without condylar ... -
JTC-801 Suppresses Melanoma Cells Growth through the PI3K‑Akt‑mTOR Signaling Pathways
(EDP Sciences, 2018)Melanoma is considered as one of the most potentially fatal and aggressive malignancies. Due to the limited efficacy or drug resistance of the current targeted therapies of melanoma, developing new therapeutic drugs against ... -
Knock-down of filaggrin influences the mitogen-activated protein kinases signaling pathway in normal human epidermal keratinocytes
(EDP Sciences, 2018)Background: Filaggrin is an essential structural protein of the stratum corneum binding to the keratin intermediate filaments to form a dense protein-lipid matrix. However, the function of filaggrin in epidermal terminal ... -
Laparoscopic combined with hysteroscopic repair or operative hysteroscopy in the treatment of symptomatic cesarean-induced diverticulum
(EDP Sciences, 2018)Objective: The postmenstrual bleeding with cesarean-induced diverticulum is a bothersome symptom and can be confused with other abnormal-uterine bleeding disease. The aim of the present study was to evaluate the efficacy ... -
Liuwei Dihuang exhibits antidiabetic effects through inhibiting α-amylase and α-glucosidase
(EDP Sciences, 2018)Objective: Liuwei Dihuang (LWDH) is a famous traditional herbal medicine formula in China that may regulate the balance of kidney yin yang and has been used to restore functional insufficiency of the kidney for a long time ... -
Lycorine inhibits melanoma A375 cell growth and metastasis through the inactivation of the PI3K/AKT signaling pathway
(EDP Sciences, 2018)Malignant melanoma, one of the most aggressive skin cancers, has a very high mortality rate. Currently, the number of drugs to treat melanoma is low. Although new immunotherapeutic approaches based on the use of antibodies ... -
miR-25 Promotes Melanoma Progression by regulating RNA binding motif protein 47
(EDP Sciences, 2018)Melanoma is the most aggressive skin cancer, and accounts for the major part of skin cancer-related deaths in the world. In addition, the underlying mechanism of tumor progression in melanoma remains far from being elucidated. ... -
NPS - 2143 (hydrochloride) inhibits melanoma cancer cell proliferation and induces autophagy and apoptosis
(EDP Sciences, 2018)Melanoma is a common and aggressive skin cancer caused by the oncogenic transformation of melanocytes. NPS-2143 (hydrochloride) is a calcification drug that acts as an antagonist of the calcium-sensing receptor (CaSR) and ... -
Overexpression of RBM10 induces osteosarcoma cell apoptosis and inhibits cell proliferation and migration
(EDP Sciences, 2018)Osteosarcoma is the most common malignant bone tumor with high incidence in adolescence and poor prognosis. RBM10, a member of RBPs, was reported to be a tumor suppressor in many kinds of cancers. However, the roles of ... -
Overexpression of SLC25A15 is involved in the proliferation of cutaneous melanoma and leads to poor prognosis
(EDP Sciences, 2018)Melanoma is a skin tumor with a high degree of malignancy, poor prognosis and few effective therapies. Deprivation of the arginine from cancer cells through transport inhibition and arginine depletion is a novel strategy ... -
Relationship between depression and blood cytokine levels in lung cancer patients
(EDP Sciences, 2018)Objective: To study the correlation between depression and blood cytokine levels in lung cancer patients. Methods: 92 patients with advanced lung cancer were evaluated for depression using the scoring index of depression ...