dc.contributor.author | Jordan, Bertrand | - |
dc.date.accessioned | 2020-12-07T10:24:21Z | |
dc.date.available | 2020-12-07T10:24:21Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Jordan, Bertrand ; Les pièges de l’amélioration : Chroniques génomiques, Med Sci (Paris), Vol. 35, N° 8-9 ; p. 709-711 ; DOI : 10.1051/medsci/2019136 | |
dc.identifier.issn | 1958-5381 | |
dc.identifier.uri | http://hdl.handle.net/10608/10455 | |
dc.description.abstract | Inactivation of the CCR5 gene by CRISPR editing in human
embryos, as recently attempted in China, was touted as a positive change for the
babies involved since it was expected to impart resistance to HIV infection.
However, it turns out that the absence of CCR5 is not neutral
but actually decreases fitness, as shown by survival analysis of population data
in the UK biobank. This underlines the pitfalls of genetic enhancement, and
emphasizes that any germline modification must be preceded by in-depth studies
to exclude unforeseen negative effects. | en |
dc.language.iso | fr | |
dc.publisher | EDP Sciences | |
dc.relation.ispartof | Forum | |
dc.rights | Article en libre accès - License CC BY 4.0 [http://creativecommons.org/licenses/by/4.0] | fr |
dc.rights | Médecine/Sciences - Inserm - SRMS | fr |
dc.source | M/S. Médecine sciences [ISSN papier : 0767-0974 ; ISSN numérique : 1958-5381], Vol. 35, N° 8-9; p. 709-711 | |
dc.subject.mesh | Adulte | fr |
dc.subject.mesh | Sujet âgé | fr |
dc.subject.mesh | Systèmes CRISPR-Cas | fr |
dc.subject.mesh | Chine | fr |
dc.subject.mesh | Recherche sur l'embryon | fr |
dc.subject.mesh | Édition de gène | fr |
dc.subject.mesh | Extinction de l'expression des gènes | fr |
dc.subject.mesh | Amélioration génétique | fr |
dc.subject.mesh | Étude d'association pangénomique | fr |
dc.subject.mesh | Infections à VIH | fr |
dc.subject.mesh | VIH-1 (Virus de l'Immunodéficience Humaine de type 1) | fr |
dc.subject.mesh | Humains | fr |
dc.subject.mesh | Longévité | fr |
dc.subject.mesh | Adulte d'âge moyen | fr |
dc.subject.mesh | Récepteurs CCR5 | fr |
dc.subject.mesh | éthique | fr |
dc.subject.mesh | physiologie | fr |
dc.subject.mesh | génétique | fr |
dc.subject.mesh | prévention et contrôle | fr |
dc.title | Chroniques génomiques - Les pièges de l’amélioration | fr |
dc.title.alternative | Enhancement can do harm | en |
dc.type | Article | |
dc.contributor.affiliation | UMR 7268 ADÉS, Aix-Marseille, Université /EFS/CNRS; CoReBio
PACA, case 901, Parc
scientifique de Luminy, 13288
Marseille Cedex 09,
France | |
dc.identifier.doi | 10.1051/medsci/2019136 | |
dc.identifier.pmid | 31532388 | |