Chroniques génomiques : Le Junk DNA n’est plus ce qu’il était
Résumé
A systematic search for non-conventional open reading frames in human DNA reveals a large number of small ORFs encoding peptides generally smaller than 100 amino-acids. These ORFs are transcribed and translated into small proteins, which are demonstrated to have functional significance by bulk CRISPR inactivation. Evidence is also found for bicistronic mRNAs including such a small ORF upstream of a canonical coding sequence. These findings add a new facet to our understanding of biological processes.
Pour citer ce document
Jordan, Bertrand ; Chroniques génomiques : Le Junk DNA n’est plus ce qu’il était, Med Sci (Paris), Vol. 36, N° 6-7 ; p. 675-677 ; DOI : 10.1051/medsci/2020108