Chroniques génomiques - Ces bons mutants qui éliminent les tumeurs

Abstract

Most (>90%) of the nascent tumours present in murine oesophageal epithelium after mutagen treatment disappear during the following months. This elimination is driven by mutant (but phenotypically normal) clones that gradually outcompete and eliminate the neoplastic clones. This novel mechanism, demonstrated in the mouse, is probably active in humans as well and may have important clinical implications.