La production de protéines à usage biopharmaceutique dans les plantes.
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Initially characterized as the agents responsible for plant «tumor» formation, agrobacteria have evolved a type IV secretion system to export a specific segment of a particular plasmid and address it to plant nuclei. Over the last century, the conjunction of research in plant pathology, cell biology, and ultimately in microbiology, led to the understanding of the process of gene transfer. In the natural process, the genes transfered to the plant create a metabolic pathway for the benefit of the bacteria. Once understood, this process has been diverted by biologists to provide a technique of gene transfer, which has become the most widely used for plants. However, it remains to unravel the details of the mechanism of integration of the bacterial DNA in the host genome.
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Faye, L ; Landry, N ; Lerouge, P ; Gomord, V ; Vézina, LP, La production de protéines à usage biopharmaceutique dans les plantes., Med Sci (Paris), 2001, Vol. 17, N° 8-9; p.867-77