According to recent reports, the success rate of targeted therapy directed by “actionable mutations” found in tumour DNA is rather low (10 to 20%). Interesting attempts have been made to improve this by establishing mouse ...

A newly developed technique allows the analysis of gene expression within tissues at near-cellular resolution. This opens a whole range of applications and will be a major ingredient of future studies.

A novel gene editing procedure based on a nuclease from the Argonaute protein family was described in mid-2016 and appeared to provide significant advantages over the now widely used CRISPR-Cas9 system. Attempts by numerous ...

Senescent cells are involved in many age-related diseases, and the effects of their elimination by “senolytic” drugs is an active research field. A recent paper describes a convenient murine model of induced senescence and ...

Large differences in maximum longevity exist between different rodent species. Determination of the spontaneous and mutagen-induced mutation rates in these species by single (somatic) cell sequencing suggests more efficient ...

The elimination of some senescent cells by « senolytic » compounds can greatly improve the health of aged mice and in some cases reverse the effects of aging. Using a microbial exposure system that closely models coronavirus ...

Hutchinson-Gilford Progeria (acute premature aging) is caused by a de novo point mutation in the lamin A gene. Recently, this mutation has been accurately corrected by base editing in patient cell lines and in a mouse ...