dc.contributor.author | Rabenandrasana, C. | fr_FR |
dc.contributor.author | Ramsohoye, P. | fr_FR |
dc.date.accessioned | 2013-02-15T11:58:37Z | |
dc.date.available | 2013-02-15T11:58:37Z | |
dc.date.issued | 1994 | fr_FR |
dc.identifier.citation | Rabenandrasana, C. ; Ramsohoye, P., La clusterine : une nouvelle glycoprotéine protectrice de l'intégrité cellulaire ?, Med Sci (Paris), 1994, Vol. 10, N° 1; p.12-20 | fr_FR |
dc.identifier.issn | 1958-5381 | fr_FR |
dc.identifier.uri | http://hdl.handle.net/10608/2476 | |
dc.description.abstract | Clusterin, a heterodimeric glycoprotein has emerged in scientific reports from disparate fields of cell biology. This molecule is widely expressed in mammalian species. Clusterin has been associated to physiological functions including cell-cell interactions, immune defense secretion and lipid transport. A marked induction of clusterin level has been reported during neurodegenerative diseases and renal injuries. The measurement of clusterin could be used as a clinical marker of these pathologies. Its ability to inhibit complement mediated lysis and its lipid-binding capacity confer to clusterin qualities for cellular membrane protection. This molecule could serve as a protective mechanism against immunological activation fo complement system occurring after tissue injury and to maintain cell membrane integrity in a physiological state against noxious hydrophobic molecules. | fr |
dc.language.iso | fr | fr_FR |
dc.publisher | John Libbey Eurotext, Montrouge | fr_FR |
dc.rights | Article en libre accès | fr |
dc.rights | Médecine/Sciences - Inserm - SRMS | fr |
dc.source | M/S. Médecine sciences [revue papier, ISSN : 0767-0974], 1994, Vol. 10, N° 1; p.12-20 | fr_FR |
dc.title | La clusterine : une nouvelle glycoprotéine protectrice de l'intégrité cellulaire ? | fr |
dc.type | Article | fr_FR |
dc.identifier.doi | 10.4267/10608/2476 | |