Contrôle des cellules de Langerhans par le GM-CSF

Abstract

Langerhans cells are dendritic cells, which initiate the antigen specific immune response. They internalize and process the antigen. The they migrate from the epithelium to the draining lymph node, where they present the antigen to the T cells. Granulocyte/macrophage colony-stimulating factor (GM-CSF) induces differentiation, proliferation of Langerhans' cell precursors, and activation of Langerhans' cells in vitro. GM-CSF also induces accumulation of Langerhans' cells in vivo. Therefore, GM-CSF is one of the main immune response initiating factors.