La motiline. De l'animal à l'homme

Abstract

Motilin is one of the numerous peptides found in intestinal mucosa. In animals, plasma motilin variations were associated with the regulation of the migrating motor complex. The place of motilin in human physiology has still to be clarified but its importance for the clinician is gradualy emerging. Stimulation of motilin receptors present in the human antrum elicits most potent contractions of this region of the stomach and motilin (or a derivative of motilin) could in the near future constitute the most efficient regimen for the treatment of gastroparesis.