Explorer de nouveaux domaines SH2/SH3

Abstract

SH2 domains have been found in a wide range of non receptor tyrosine kinases, such as GAP, phospholipase Cy-1 and the non catalytic phosphorylated regions in growth factor tyrosine kinases. A better understanding of SH2 containing proteins should increase knowledge of the mechanism by which external signalling events effect the growth and differentiation of cells. Reagents with SH2 domains offer a new approach to study fundamental questions linked to signal transduction.