dc.contributor.author | Coulier, F. | fr_FR |
dc.contributor.author | Pizette, S. | fr_FR |
dc.contributor.author | Batoz, M. | fr_FR |
dc.contributor.author | Birnbaum, D. | fr_FR |
dc.date.accessioned | 2013-02-20T14:28:36Z | |
dc.date.available | 2013-02-20T14:28:36Z | |
dc.date.issued | 1992 | fr_FR |
dc.identifier.citation | Coulier, F. ; Pizette, S. ; Batoz, M. ; Birnbaum, D., Les récepteurs des facteurs de croissance des fibroblastes: une famille qui s'agrandit, Med Sci (Paris), 1992, Vol. 8, N° 8; p.811-818 | fr_FR |
dc.identifier.issn | 1958-5381 | fr_FR |
dc.identifier.uri | http://hdl.handle.net/10608/3232 | |
dc.description.abstract | The fibroblast growth factors (FGF) are a family of seven polypeptides, the physiological importance of which has been early recognized. By contrast, their receptors have been identified only recently : they consist of protein tyrosine kinases, and of proteoglycans that serve as accessory molecules. Four genes code for receptor tyrosine kinases that, through alternative splicing mechanisms, generate multiple receptor moieties. A single proteoglycan has been formally identified as receptor for the FGFs, but several clues led to suggest that this syndecan is but one member of a whole family of proteins. The FGFs and their receptors constitute a unique example of double redundancy, as each FGF seems to associate to several receptor molecules, which in turn bind several FGFs. The advantages of such a profusion are not well understood, and several explanations are discussed. | fr |
dc.language.iso | fr | fr_FR |
dc.publisher | John Libbey Eurotext, Montrouge | fr_FR |
dc.rights | Article en libre accès | fr |
dc.rights | Médecine/Sciences - Inserm - SRMS | fr |
dc.source | M/S. Médecine sciences [revue papier, ISSN : 0767-0974], 1992, Vol. 8, N° 8; p.811-818 | fr_FR |
dc.title | Les récepteurs des facteurs de croissance des fibroblastes: une famille qui s'agrandit | fr |
dc.type | Article | fr_FR |
dc.identifier.doi | 10.4267/10608/3232 | |