Chroniques génomiques - Hétérogénéité des tumeurs : l’apport du séquençage sur cellules individuelles

Abstract

The heterogeneity of tumours is now beginning to be documented precisely by single-cell new-generation sequencing. Recently published results on breast tumours show that each of the cells analysed displays a unique pattern of point mutations. This extensive genetic diversity is present before any treatment, and is likely to cause resistance to initially successful targeted therapies.