Recherche
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Bases alternatives et organismes synthétiques : Chroniques Génomiques
(EDP Sciences, 2018)
Alternative bases that can fit into the DNA double helix have now been used in vivo to direct the synthesis of proteins incorporating unnatural amino acids. This bioengineering feat is significant at both the conceptual ...
Chroniques génomiques - Dépister les cancers asymptomatiques ?
(EDP Sciences, 2018)
A recent publication describes a sophisticated “liquid biopsy” procedure that analyses both tumoral DNA and proteins present in peripheral blood to provide sensitive detection of different types of cancer. These results ...
Hémophilie : la thérapie génique, enfin… : Chroniques Génomiques
(EDP Sciences, 2018)
Recent efforts at gene therapy for haemophilia A and B using AAV-derived vectors show durable expression of coagulation factors at significant levels, resulting in almost complete correction of the phenotype. This is the ...
Cancer : Thérapies « complémentaires » et observance du traitement anti-tumoral font-elles bon ménage ?
(EDP Sciences, 2018)
A recent paper shows that cancer patients using complementary therapies in addition to conventional treatment have distinctly worse outcomes. Analysis of the data shows that they are much more likely to refuse one component ...
Chroniques génomiques - De HGP-write aux « super-cellules »
(EDP Sciences, 2018)
The HGP-write project, announced in 2016 but not really implemented yet, comes back as a project aimed at constructing an “ultra-safe” human cell line fully resistant to virus infection and with other desirable characteristics. ...
Chroniques génomiques - Balayage du génome et repérage des personnes à risque : Des GWAS aux GPS
(EDP Sciences, 2018)
The accumulation of extensive repositories linking phenotypic and genetic information, together with new computation methods, makes it possible to derive polygenic scores for susceptibility to common diseases that turn out ...