Liuwei Dihuang exhibits antidiabetic effects through inhibiting α-amylase and α-glucosidase
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Objective: Liuwei Dihuang (LWDH) is a famous traditional herbal medicine formula in China that may regulate the balance of kidney yin yang and has been used to restore functional insufficiency of the kidney for a long time in China. Methods: In this study, the water extract of LWDH was tested for its α-Amylase and α-Glucosidase inhibitory activities, and its anti-diabetic property in streptozotocin (STZ)-induced diabetic mice was also analyzed. Results: LWDH extract inhibited α-Glucosidase and α-Amylase activities in a dose- dependent manner. Treatment of streptozotocin-induced diabetic mice with LWDH extract decreased camp, fasting blood glucose, TC, TG, LDL-c, HbA1C, Urine volume levels and Urine sugar, increased HDL-c level when compared to STZ induced diabetic mice. Conclusion: This study demonstrates that extract of LWDH can inhibit α-amylase and α-glucosidase activities and shows anti-diabetic effect in a mice preclinical model.
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Wang, Huafu ; Gang, Huang ; Zhou, Shuxin ; Liu, Lixian ; Ding, Ting ; Gui, Zhihong ; Chu, Weihua ; Liuwei Dihuang exhibits antidiabetic effects through inhibiting α-amylase and α-glucosidase, Med Sci (Paris), , Vol. 34, N° HS ; p. 4-7 ; DOI : 10.1051/medsci/201834f101