Parcourir par sujet "Étude d'association pangénomique"
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Chroniques génomiques - 23andMe et le mal des transports
(Éditions EDK, Groupe EDP Sciences, 2016)A Genome Wide Association Study on propensity to motion sickness published by 23andMe gives interesting results, shows validity for self-reported phenotypic information and underlines the value of the model developed by ... -
Chroniques génomiques - Balayage du génome et repérage des personnes à risque : Des GWAS aux GPS
(EDP Sciences, 2018)The accumulation of extensive repositories linking phenotypic and genetic information, together with new computation methods, makes it possible to derive polygenic scores for susceptibility to common diseases that turn out ... -
Chroniques génomiques - Clap de fin pour le « gène de l’homosexualité »
(EDP Sciences, 2020)Evidence for a “homosexuality gene” was claimed in the early 1990’s on the basis of linkage studies that, by current criteria, were woefully underpowered. Indeed, follow up studies gave contradictory results. Genome-wide ... -
Chroniques génomiques - Couleur de la peau chez l’homme : de nouvelles surprises
(EDP Sciences, 2019)Careful GWAS analysis of a group of mixed-ancestry Latino-American individuals reveals the role of a new “light” variant of the MSFD12 gene which appears to originate in some of the ... -
Chroniques génomiques - Encore le « gène du crime » ?
(Éditions EDK, Groupe EDP Sciences, 2015)A new genetic study focussing on the degree of violence in criminals and using both candidate gene and GWAS approaches finds statistically significant associations of extreme violent behaviour with low activity alleles of ... -
Chroniques génomiques - Les pièges de l’amélioration
(EDP Sciences, 2019)Inactivation of the CCR5 gene by CRISPR editing in human embryos, as recently attempted in China, was touted as a positive change for the babies involved since it was expected to ... -
Chroniques génomiques - Les « gènes » de la schizophrénie
(Éditions EDK, Groupe EDP Sciences, 2014)Very large-scale GWAS analyses confirm the genetic complexity of schizophrenia and provide some new leads to understand the etiology of the condition. -
Chroniques génomiques - Scores polygéniques et risque de cancer
(EDP Sciences, 2020)Risk assessment for a cancer type with moderate heritability can be accurately performed using a relatively small number of SNPs detected by GWAS analyses to calculate a polygenic risk score (PRS) that has definite clinical ... -
Chroniques génomiques - Séquencer les bébés ?
(Éditions EDK, Groupe EDP Sciences, 2015)An extension of newborn screening to genome sequencing is now feasible but raises a number of scientific, organisational and ethical issues. This is being explored in discussions and in several funded trials, in order to ... -
Chroniques génomiques - Taille à l’âge adulte : une myriade de locus
(EDP Sciences, 2023)The combination of 281 GWAS studies for adult height leads to the identification of 12,111 SNP in 7,209 loci that together account for essentially all SNP heritability for this trait: there is no longer any significant ... -
Chroniques génomiques - Un cadeau empoisonné
(EDP Sciences, 2020)GWAS analysis of severe Covid patients implicates a major locus on chromosome 3. The corresponding 50 kb segment appears to originate from Neanderthal/Sapiens crossings, raising interesting evolutionary questions. -
Chroniques génomiques - Une question de pigmentation
(EDP Sciences, 2018)GWAS analyses for skin colour performed on a series of diverse African groups reveal new loci involved in this phenotype and, surprisingly, the presence within several African populations of the “light” allele of the SLC24A5 ... -
Chroniques génomiques - Variants fréquents et rares, caractères multigéniques et héritabilité perdue
(Éditions EDK, Groupe EDP Sciences, 2017)Recently, a systematic (but limited) search for rare variants implicated in adult height, a highly polygenic trait, has uncovered a number of new variants for which the effect size is inversely correlated with the minor ... -
Chroniques génomiques : Du bon usage des exomes
(EDK, 2010) -
Chroniques génomiques : Le véritable « génome personnel » ?
(Éditions EDK/Groupe EDP Sciences, 2011)Comme on l’a dit et répété dans ces colonnes [1–3], la valeur prédictive des profils génétiques à base de Snip vendus par 23andMe, Navigenics et autres « entreprises DTC » (direct to consumer) est très faible pour ne pas ... -
Chroniques génomiques : Notre génome est-il prédictif ?
(Éditions EDK/Groupe EDP Sciences, 2012) -
Chroniques génomiques : Nous avons les moyens de faire parler votre ADN…
(Éditions EDK/Groupe EDP Sciences, 2011) -
Chroniques génomiques : Snip et histoire familiale : le match !
(Éditions EDK/Groupe EDP Sciences, 2013) -
Chroniques génomiques : The sound of silence
(Éditions EDK/Groupe EDP Sciences, 2012)