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Chroniques génomiques : Snip et histoire familiale : le match !
(Éditions EDK/Groupe EDP Sciences, 2013)
Bébés CRISPR : Anatomie d’une transgression
(EDP Sciences, 2019)
Analysing the data recently presented by Jiankui He and assuming that it is authentic shows that the goal of abolishing the expression of CCR5 may have been reached for one of the resulting twins, although this remains to ...
Chroniques génomiques - Modification ciblée du génome : une nouvelle approche prometteuse
(Éditions EDK, Groupe EDP Sciences, 2017)
A new approach, based on the use of peptide nucleic acid molecules to form triple helices and promote locus-specific recombination, demonstrates potential for in vivo gene correction at clinically significant levels and ...
Chroniques génomiques - Synthétique, vous avez dit « Synthétique » ?
(Éditions EDK, Groupe EDP Sciences, 2016)
The synthesis of a minimal bacterial genome comprising only 473 genes is an impressive achievement, yet it is only a step towards a really synthetic genome based on first principles: this set of genes was derived from a ...
Chroniques génomiques - Actualités du séquençage d’ADN
(EDP Sciences, 2019)
The planned acquisition of Pacific Biosciences by Illumina could signal a big change in the DNA sequencing landscape, and provides the incentive for an update on a field that still has a number of players and could be ...
Chroniques génomiques - Slide-seq : L'analyse d'expression à haute résolution spatiale
(EDP Sciences, 2019)
A newly developed technique allows the analysis of gene expression within tissues at near-cellular resolution. This opens a whole range of applications and will be a major ingredient of future studies.
Chroniques génomiques - Immunothérapie « CAR-T » : une autorisation qui fait date
(Éditions EDK, Groupe EDP Sciences, 2017)
The first therapy based on chimeric antigen receptors has been approved by the FDA. It gives excellent results in recurrent paediatric ALL; its cost is very high but fairly consistent with the clinical benefit (long term ...
Chroniques génomiques - Les Argonautes ont-ils perdu le Nord ?
(Éditions EDK, Groupe EDP Sciences, 2017)
A novel gene editing procedure based on a nuclease from the Argonaute protein family was described in mid-2016 and appeared to provide significant advantages over the now widely used CRISPR-Cas9 system. Attempts by numerous ...
Chroniques génomiques - Des résultats tout à fait inattendus
(Éditions EDK, Groupe EDP Sciences, 2015)
There are now a number of cases in which non-invasive prenatal testing (NIPT) has detected signs of cancer in pregnant women. These unexpected findings raise a number of difficult questions regarding their communication ...
Chroniques génomiques - CRISPR sur embryons humains : une nouvelle étape
(Éditions EDK, Groupe EDP Sciences, 2017)
Viable human embryos carrying a disease mutation have now been corrected by CRISPR-Cas9 editing. Although the correction is not perfect, and the embryos have not been implanted, this brings us closer to human germline ...