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Chroniques génomiques - Thérapie génique germinale, le retour ?
(Éditions EDK, Groupe EDP Sciences, 2015)
The recent development of a powerful and flexible genome editing technique (the CRISP-cas9 method) accelerates tremendously the production of animal models and will significantly enhance the perspectives of (somatic) gene ...
Chroniques génomiques - Séquençage d’ADN: l’offensive des nanopores
(Éditions EDK, Groupe EDP Sciences, 2017)
A practical DNA sequencer based on nanopores has now demonstrated interesting performance and may be on the way to capturing a significant slice of the sequencing market while opening up new application fields thanks to ...
Chroniques génomiques - CRISPR-Cas9, une nouvelle donne pour la thérapie génique
(Éditions EDK, Groupe EDP Sciences, 2015)
Targeted modification of genes (“gene editing”) is made much easier by the recently developed CRISPR-Cas9 system. This has raised alarm about possible uses of this technology for germline modification of the human genome; ...
Chroniques génomiques - 23andMe et le mal des transports
(Éditions EDK, Groupe EDP Sciences, 2016)
A Genome Wide Association Study on propensity to motion sickness published by 23andMe gives interesting results, shows validity for self-reported phenotypic information and underlines the value of the model developed by ...
Chroniques génomiques : L’intimité génétique existe-t-elle encore ?
(Éditions EDK/Groupe EDP Sciences, 2011)
Chroniques génomiques - Biopsies liquides, une révolution en cancérologie ?
(Éditions EDK, Groupe EDP Sciences, 2015)
The detection and analysis of circulating tumour DNA and/or circulating tumour cells in the blood of cancer patients open new possibilities for cancer characterisation and management. The approach has generated much ...
Chroniques génomiques - L’invasion des tests non invasifs
(EDP Sciences, 2014)
Non-invasive prenatal testing is becoming commonplace, but, in addition, other tests using only a blood sample are being developed and will have a significant impact, notably in oncology.
Bébés CRISPR : Anatomie d’une transgression
(EDP Sciences, 2019)
Analysing the data recently presented by Jiankui He and assuming that it is authentic shows that the goal of abolishing the expression of CCR5 may have been reached for one of the resulting twins, although this remains to ...
Chroniques génomiques - Modification ciblée du génome : une nouvelle approche prometteuse
(Éditions EDK, Groupe EDP Sciences, 2017)
A new approach, based on the use of peptide nucleic acid molecules to form triple helices and promote locus-specific recombination, demonstrates potential for in vivo gene correction at clinically significant levels and ...
Chroniques génomiques - Synthétique, vous avez dit « Synthétique » ?
(Éditions EDK, Groupe EDP Sciences, 2016)
The synthesis of a minimal bacterial genome comprising only 473 genes is an impressive achievement, yet it is only a step towards a really synthetic genome based on first principles: this set of genes was derived from a ...