Spécificité de l'action des protéine kinases et phosphatases dans la cellule

Abstract

The broad substrate specificity of most of the kinases and phosphatases, the enzymes involved in the reversible phosphorylation of proteins, must be restricted in vivo to further ensure an efficient and precise signaling. Here we review recent evidence indicating that at least two families of kinases and one family of phosphatases use a similar strategy to their catalytic subunit towards their specific substrates. The targeting subunit of these modular enzymes could direct the catalytic subunit to their appropriate target locus. The centrosome, the organiser of cell microtubules, is chosen to illustrate a privileged target locus for several kinases and phosphatases, using such a targeting subunit strategy.