Recherche
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Chroniques génomiques - De l’exome à l’avatar : vers une « oncologie de précision » ?
(Éditions EDK, Groupe EDP Sciences, 2014)
According to recent reports, the success rate of targeted therapy directed by “actionable mutations” found in tumour DNA is rather low (10 to 20%). Interesting attempts have been made to improve this by establishing mouse ...
Chroniques génomiques - Les leçons inattendues d’Hiroshima
(Éditions EDK, Groupe EDP Sciences, 2014)
One of the initial motivations for the Genome project was to improve the detection of possible mutations in children of atomic bomb survivors. In fact it has proved very difficult to find any genetic effect in these ...
Course à la lune en biologie : Chroniques génomiques
(Éditions EDK, Groupe EDP Sciences, 2014)
Three recent and very large projects aim to integrate several “omics” approaches in order to promote pro-active medicine and to create a “Wellness industry”.
Chroniques génomiques - Hétérogénéité des tumeurs : l’apport du séquençage sur cellules individuelles
(Éditions EDK, Groupe EDP Sciences, 2014)
The heterogeneity of tumours is now beginning to be documented precisely by single-cell new-generation sequencing. Recently published results on breast tumours show that each of the cells analysed displays a unique pattern ...
Chroniques génomiques - Les « gènes » de la schizophrénie
(Éditions EDK, Groupe EDP Sciences, 2014)
Very large-scale GWAS analyses confirm the genetic complexity of schizophrenia and provide some new leads to understand the etiology of the condition.